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In the SURMOUNT-1 trial, people treated with tirzepatide lost up to 22.5% of their body weight over 72 weeks , making it even more effective than semaglutide (NEJM tirzepatide study)

(PubMed) Sawka AM, Ray JG, Yi Q, Josse RG, Lonn E

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The combination is frequently utilised in controlled research environments focused on peptide-mediated biological processes, cellular signalling pathways and molecular communication systems